TOOL BOX
High-throughput sequencing (HTS) technologies have greatly facilitated the studies on genomics, transcriptomics, epigenomics and microbiomics,
also HTS capable of sequencing multiple DNA molecules simultaneously.
This advantage allows HTS
to create a large amount of data,
gaining more comprehensive
insights into our researches.
HTS technologies are commonly used in researches
to identify novel variants, analyze transcriptome changes,
identify epigenetic changes, and more.
These applications encompass
whole genome/exon sequencing, RNA sequencing,
chromatin immunoprecipitation sequencing,
studying the human microbiome,
and ribosome sequencing.
whole genome/exon sequencing, RNA sequencing,
chromatin immunoprecipitation sequencing,
studying the human microbiome,
and ribosome sequencing.
High-throughput sequencing has many applications in a wide range of fields, including:
Cancer genomics
HTS can be used to identify genetic mutations and alterations that drive cancer development and progression, providing insights into the molecular mechanisms of cancer and potential targets for therapy.
Epigenomics
HTS can be used to study epigenetic modifications, such as DNA methylation and histone modifications, which play a critical role in gene expression and development.
Forensic analysis
HTS can be used in forensic investigations to identify suspects, victims, and the origin of biological samples found at a crime scene.
Genome sequencing
HTS can be used to sequence entire genomes of different organisms, from bacteria to humans, providing a detailed understanding of genetic variation and evolution.
Metagenomics
HTS can be used to study the entire microbial community in a given environment, including the human microbiome, soil, and water, providing insights into microbial diversity, ecology, and function.
Transcriptome analysis
HTS can be used to sequence the entire transcriptome, which is the set of all RNA molecules in a cell, tissue, or organism. This allows researchers to identify differentially expressed genes, splice variants, and non-coding RNA molecules, providing insights into gene regulation and cellular processes.
Overall, HTS has transformed the field of genomics and
has had a profound impact on many areas of biological and medical research,
leading to new insights into the genetic basis of diseases and the development
of new diagnostics and therapies.
has had a profound impact on many areas of biological and medical research,
leading to new insights into the genetic basis of diseases and the development
of new diagnostics and therapies.
Prof. Ying-Tsong Chen / 陳盈璁 老師
微生物基因體核心研究室
Microbial Genomics Core Laboratory
- Office:04-22840338#7101
- Lab:04-22840338#7111
- E-mail: onion@nchu.edu.tw
- Address:
Institute of Genomics and Bioinformatics,
National Chung Hsing University
中興大學基因體暨生物資訊學研究所
Dr. Li-Ching Hsieh / 謝立青老師
計算與演化基因體核心實驗室
Computational & Evolutionary Genomics Core Lab
- Office：04-2284-0338#7091
- Lab：04-2284-0338#7081
- E-mail: liching@dragon.nchu.edu.tw
- Address:
Institute of Genomics and Bioinformatics,
National Chung Hsing University
中興大學基因體暨生物資訊學研究所